Comparing them one at a time is much too easy. Let's tear each one apart individually and see how they add up.
Mwahaha?
NOTE: THE FOLLOWING ARE ALL JUST PERSONAL OPINIONS AND I AM NOT LIABLE FOR HURT FEELINGS!
I shall list them in the order of which I prefer the most.
The Original Manga -
Storyline wise, while it does have a few story arcs here and there, is mostly just a long comic that can mostly be read in whatever order. I suppose this is why it was able to be published in order of which stories Tezuka liked the most (this was done because they didn't know if they could publish them all - lawls). But, the stories that are told are actually pretty deep most of the time. They get some real depth and don't just throw a bunch of blind action sequences at you like some of the more modern manga. There is comedy thrown in here and there, but the more serious stories have a real thrill to them that makes them more memorable than some of the anime series'.
Character wise, I believe the manga shows them in their purest form - in the way that Tezuka originally designated them to be. This being said, I think that they have the most development in the manga than anywhere else. I also prefer the Astro in the manga than in any of the anime ones. This one is, of course, the one that Tezuka originally envisioned and seems to have the innocence that Astro is meant to portray. Well, that's what I think, anyway...(Also, Shunsaku Ban gets more face time in the manga. :3 Hurrah!)
Art wise, I love it. I know it's over 50 years old, but so what? It looks great! It's got a quality to it that a lot of the modern manga cannot even compare to! Also, many of the jokes that Tezuka projects through his unusual style of drawing pages really adds to the charm. (Like in one chapter where Tawashi and the police department hides a bunch of paintings behind a panel on the next page, lawls.) It's really something that separates this series - and for that matter, all of Tezuka's works - from anything else in the world of comic books.
The Anime (collectively) -
Storyline wise, while the first two series just had a bunch of episodes that could be shown in whatever order, the third series really seemed to follow more of a straight plot. Not so much in the first season, but really in the second season (which is a bit of an oddity in the Astro-verse, so to speak). They mostly copied stories from the manga, so some of the feeling seemed lost from the originals from time to time...I dunno...
Character wise, they kinda went the same as the storyline. A bit seems lost from movement to anime through all three series. I'm not sure any of them have really captured the same Astro that was shown through Tezuka's pen. (I guess if you combined the 60's Astro and the 03 Astro, you'd have it, but...)
Art wise, the 60's series was pretty close to the original manga, which was pretty streamline and clean. I like it. Simple, but looks great. The 80's series always looks so busy. I guess that was the style of the time, but I really didn't like the way Astro looks in this series compared to others. He's so short. >.< Now, the 03 series is a mixed pot. Astro looks great, but some of the characters just look too different. Epsilon is a good example. Yeesh. But, Pluto was an improvement, so not all of it was bad. I have mixed feelings on this one...hehehe...
The Movie -
My opinion on the Characters, Storyline and Art can all be summed up with one simple statement:
It doesn't compare to the manga or anime because it kept nothing from them. In my opinion, it's just a mess. I guess that's what it gets for being made in America. Blech. (They should have learned from NOW!'s mistakes, lawls).
Eww, how can you make something that bad from something good?
like she said, food coloring instead of actual flavor and no yeast.